Overview#

Welcome to the GSCN Workshop materials! This book contains the workshop materials organized by day:

Each day contains its own set of notebooks and materials for the workshop.

Before the event#

Tech setup#

In addition to the actual workshop, we offer two pre-workshop sessions designed to help participants with any issues installing software required for the workshop. During these, we also encourage participants to ask questions about basic Python/Jupyter Notebook usages (the notebook discussed in these sessions can be found here). The two sessions take place on:

  • Wednesday (02.04.2025), 15:00 - 17:00 CET

  • Thursday (03.04.2025), 15:30 - 17:30 CET

The Zoom links to these events can be found in the mail sent on Sunday, 30.03.2025. If you have any other questions, please direct them to the 2025-04: Workshop GSCN > pre-workshop support Zulip channel.

Syllabus#

Note: Schedule subject to minor adjustments.

Date

Time

Activity

Monday, 07.04.2025

09:00 – 09:15

Welcome & Introduction to the Workshop

09:15 – 10:00

Talk: “An in-depth look at AnnData” by Ilan Gold

10:00 – 11:30

1) Basic pre-processing of scRNA-seq data

2) Batch effect correction

3) Downstream analysis

11:30 - 12:00

Hands-on coding & Troubleshooting

12:00 – 13:00

Lunch

13:00 – 13:30

Intro to “Trajectory analysis”

13:30 – 13:40

Break

13:40 – 15:20

Trajectory analysis

15:20 – 15:40

Break

15:40 – 17:30

Trajectory analysis

19:00 - tbd

Dinner at Porta Nova (Robert-Koch-Platz 12)

Tuesday, 08.04.2025

09:00 – 09:30

Recap and Q&A, tech setup for spatial workshop

09:30 – 10:00

Talk: “Clonal dynamics and mitochondrial genetics through the
lens of single-cell multi-omics” by Leif Ludwig

10:00 – 11:30

1) Ligand-receptor interaction analysis

2) Differential cellular abundance

11:30 - 12:00

Hands-on coding & Troubleshooting

12:00 – 13:00

Lunch

13:00 – 13:30

Intro to “Spatial Omics”

13:30 – 13:40

Break

13:40 – 15:20

Spatial preprocessing & analysis

15:20 – 15:40

Break

15:40 – 17:30

Spatial preprocessing & analysis

20:00 - tbd

Dinner (self-organised)

Wednesday, 09.042025

09:00 – 09:30

Talk: “Spatiotemporal dynamics of tumor development in a novel
triple-negative breast cancer model” by Tancredi Massimo Pentimalli

09:30 – 11:30

Talk: “Foxa2 pioneers enteroendocrine lineage recruitment from
intestinal stem cells” by Michael Sterr

10:00 – 11:30

Option A) Reproduce published figures

Option B) Discuss your own data/analysis

11:30 – 12:00

Results / Feedback